The enigmatic mossy cell of the dentate gyrus
نویسندگان
چکیده
منابع مشابه
Hilar mossy cells of the dentate gyrus: a historical perspective
THE CIRCUITRY OF THE DENTATE GYRUS (DG) OF THE HIPPOCAMPUS IS UNIQUE COMPARED TO OTHER HIPPOCAMPAL SUBFIELDS BECAUSE THERE ARE TWO GLUTAMATERGIC PRINCIPAL CELLS INSTEAD OF ONE: granule cells, which are the vast majority of the cells in the DG, and the so-called "mossy cells." The distinctive appearance of mossy cells, the extensive divergence of their axons, and their vulnerability to excitotox...
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The dentate gyrus is a simple cortical region that is an integral portion of the larger functional brain system called the hippocampal formation. In this review, the fundamental neuroanatomical organization of the dentate gyrus is described, including principal cell types and their connectivity, and a summary of the major extrinsic inputs of the dentate gyrus is provided. Together, this informa...
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Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process, akin to putting together a jigsaw puzzle ...
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Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overloo...
متن کاملRAPID COMMUNICATION Expression of C-fos in Hilar Mossy Cells of the Dentate Gyrus In Vivo
Granule cells (GCs) of the dentate gyrus (DG) are considered to be quiescent—they rarely fire action potentials. In contrast, the other glutamatergic cell type in the DG, hilar mossy cells (MCs) often have a high level of spontaneous activity based on recordings in hippocampal slices. MCs project to GCs, so activity in MCs could play an important role in activating GCs. Therefore, we investigat...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2016
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn.2016.87